Photodynamic therapy (PDT) is a new and rapidly developing treatment modality for clinical cancer therapy. Semiconductor polymer dots (Pdots) doped with photosensitizers have been successfully applied to PDT, and have made progress in the field of tumor therapy. However, the problems of severe photosensitivity and limited tissue penetration depth are needed to be solved during the implementation process of PDT. Here we developed the Pdots doped with photosensitizer molecule Chlorin e6 (Ce6) and photochromic molecule 1,2-bis(2,4-dimethyl-5-phenyl-3-thiophene)-3,3,4,5-hexafluoro-1-cyclopentene (BTE) to construct a photoswitchable nanoplatform for PDT. The Ce6-BTE-doped Pdots were in the green region, and the tissue penetration depth was increased compared with most Pdots in the blue region. The reversible conversion of BTE under different light irradiation was utilized to regulate the photodynamic effect and solve the problem of photosensitivity. The prepared Ce6-BTE-doped Pdots had small size, excellent optical property, efficient ROS generation and good photoswitchable ability. The cellular uptake, cytotoxicity, and photodynamic effect of the Pdots were detected in human colon tumor cells. The experiments in vitro indicated that Ce6-BTE-doped Pdots could exert excellent photodynamic effect in ON state and reduce photosensitivity in OFF state. These results demonstrated that this nanoplatform holds the potential to be used in clinical PDT.Photodynamic therapy (PDT) is a new and rapidly developing treatment modality for clinical cancer therapy. Semiconductor polymer dots (Pdots) doped with photosensitizers have been successfully applied to PDT, and have made progress in the field of tumor therapy. However, the problems of severe photosensitivity and limited tissue penetration depth are needed to be solved during the implementation process of PDT. Here we developed the Pdots doped with photosensitizer molecule Chlorin e6 (Ce6) and photochromic molecule 1,2-bis(2,4-dimethyl-5-phenyl-3-thiophene)-3,3,4,5-hexafluoro-1-cyclopentene (BTE) to construct a photoswitchable nanoplatform for PDT. The Ce6-BTE-doped Pdots were in the green region, and the tissue penetration depth was increased compared with most Pdots in the blue region. The reversible conversion of BTE under different light irradiation was utilized to regulate the photodynamic effect and solve the problem of photosensitivity. The prepared Ce6-BTE-doped Pdots had small size, excellent optical property, efficient ROS generation and good photoswitchable ability. The cellular uptake, cytotoxicity, and photodynamic effect of the Pdots were detected in human colon tumor cells. The experiments in vitro indicated that Ce6-BTE-doped Pdots could exert excellent photodynamic effect in ON state and reduce photosensitivity in OFF state. These results demonstrated that this nanoplatform holds the potential to be used in clinical PDT.

报道并制备一种脊波导结构的大功率1.5 μm分布反馈(DFB)激光器。为了获取最大的激光器出光功率，采用上下限制层非对称的波导结构。通过模拟仿真发现，当下限制层选择为450 nm时，该激光器具有最小的内部损耗系数，同时还能保证一阶模（m=1）在量子阱区具有最小的限制因子。实际制备的管芯的损耗系数为9.78 cm-1，这与仿真中计算的损耗系数9.3 cm-1较为符合。600 mA直流电流下，制备的法布里-帕罗(F-P)腔激光器最大功率大于114 mW；255 mA直流电流下，制备的单波长DFB激光器具有45 dB的边模抑制比，40 mW输出功率，和小于400 kHz的光谱线宽。

数字全息拼接技术旨在实现较大物体的检测或在同样的测量面积下获得更高的空间分辨力,实现方法是采集被测物体多个子孔径的数字全息图,且保持相邻子孔径之间有一定的重叠区。分别精密再现各个子孔径的数字全息图,然后将各孔径的位相信息进行拼接,以获得全孔径的位相分布。分别处理了反射型分辨力板(子孔径数为2×4)和透射性微透镜阵列(子孔径数为4×4)两个样本的全息图,并给出了消除测量光束和参考光束非等光程所引入的误差的方法。